Studies have shown that interstitial lung disease is associated with poor prognosis of RA and is considered a critical factor in the occurrence of death in RA. In addition to anemia, interstitial lung disease and Sjogren’s syndrome are also prevalent secondary lesions of RA. The main drugs for the treatment of RA comprise immunosuppressants, nonsteroidal anti-inflammatory drugs (NSAIDs), and glucocorticoids, which, however, often contribute to adverse reactions, such as liver and kidney dysfunction and gastrointestinal injury. Therefore, anemia is an important factor affecting local joint injury and systemic symptoms in RA patients.Ĭurrently, there is no radical cure for RA. In addition, anemia can lead to a range of adverse manifestations, such as fatigue, weakened muscle strength, decreased physical activity, augmented hospitalizations, and reduced quality of life. In fact, anemia is considered a predictor of radiographic progression of RA and an indicator of inflammatory status during active disease. Anemia is one of the most frequent extra-articular manifestations of RA with an incidence rate of approximately 30%–70%. Involvement of the blood system is common in multisystem damage caused by RA. RA is accompanied by multifaceted extra-articular manifestations, including rheumatoid nodules, vasculitis, pleural and pulmonary lesions, hematologic changes, cardiac lesions, renal lesions, neurological lesions, ocular lesions, and Sjogren’s syndrome. Rheumatoid arthritis (RA) is an autoimmune disease involving numerous systems, with symmetric joint pain and swelling as the main clinical manifestations, which can lead to joint deformity and loss of function. TCM, as a protective factor, is associated with a reduced risk of readmission in RA patients with anemia. In addition, the risk of readmission was dramatically diminished in the high-exposure subgroup (TCM > 12 months) compared with the low-exposure subgroup (TCM ≤ 12 months) (log-rank ). The Cox proportional hazards model showed TCM as an independent protective factor as it decreased the risk of readmission by 50% (HR = 0.50, 95% CI = 0.27–0.94, ) in RA patients with anemia. The readmission rate of RA patients with anemia was obviously lower in the TCM group than in the non-TCM group ( ). The readmission rate of anemia patients was higher than that of patients without anemia ( ).
After 1 : 1 PSM, 328 RA patients with anemia and 328 RA patients without anemia were finally included in our study. The incidence of anemia was 58.08% (471/811) in RA patients. The Kaplan–Meier survival curve was utilized to analyze the effect of TCM intervention time on readmission. The Cox proportional hazards model was used to assess the influence of various factors on the risk of readmission for RA patients with anemia. A retrospective cohort study was conducted using propensity score matching (PSM). In this study, 893 hospitalized RA patients were followed up by telephone. This study aimed to analyze the effect of traditional Chinese medicine (TCM) on the risk of readmission for rheumatoid arthritis (RA) patients with anemia.
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